At the 2026 Critics Choice Awards, comedian and host Chelsea Handler took aim with her signature humor at her former partner, rapper and actor Curtis “50 Cent” Jackson, during her opening monologue. The moment came as part of a broader stream of jabs aimed at Hollywood figures and current pop culture moments, and Handler referenced 50 Cent’s involvement in projects related to his ongoing rivalry with Sean “Diddy” Combs while acknowledging their past brief relationship.

Handler, hosting the ceremony for the fourth consecutive year, also delivered other well-received jokes at the Barker Hangar in Santa Monica, including playful digs at stars such as Leonardo DiCaprio and remarks about entertainment industry headlines, using her platform to blend comedy with pointed cultural commentary.

The evening additionally included tributes and awards presentations, with standout moments across the night drawing attention alongside Handler’s monologue that intertwined humor with personal references — including to her ex, 50 Cent — marking one of the more talked-about segments of the ceremony.

Handler’s remarks about 50 Cent added to a series of celebrity roasts throughout the show that contributed to discussions on social media and entertainment coverage following the event.